Brachyury

T brachyury transcription factor
T brachyury transcription factor
	PDB rendering based on 1xbr.
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 1xbr
Идентификаторы
Символ	T ; SAVA; TFT
Внешние ID	OMIM: 601397 MGI: 98472 HomoloGene: 2393 GeneCards: Ген T
Функция	• RNA polymerase II core promoter proximal region sequence-specific DNA binding; • RNA polymerase II distal enhancer sequence-specific DNA binding; • RNA polymerase II transcription factor binding; • RNA polymerase II activating transcription factor binding; • transcriptional repressor activity, RNA polymerase II transcription factor binding; • transcription factor activity, sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Компонент клетки	• nuclear chromatin; • nucleus; • cytoplasm;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • vasculogenesis; • somitogenesis; • neural plate morphogenesis; • neural tube closure; • heart morphogenesis; • positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; • transcription, DNA-templated; • signal transduction; • penetration of zona pellucida; • mesoderm development; • mesoderm migration involved in gastrulation; • positive regulation of cell proliferation; • anterior/posterior axis specification, embryo; • notochord formation; • signal transduction involved in regulation of gene expression; • BMP signaling pathway; • post-anal tail morphogenesis; • embryonic skeletal system development; • canonical Wnt signaling pathway; • bone morphogenesis; • SMAD protein signal transduction; • determination of heart left/right asymmetry; • cellular response to retinoic acid; • primitive streak formation;
	Источники: Amigo / QuickGO
Ортологи

Brachyury — белок, который кодируется геном Т, эмбриональный транскрипционный фактор. Входит в семейство белков с Т-боксом, играет важную роль в эмбриогенезе трехслойных животных.